This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Londoño, D.
Right arrow Articles by Cadavid, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Londoño, D.
Right arrow Articles by Cadavid, D.

 Previous Article  |  Next Article 

Infection and Immunity, December 2008, p. 5508-5513, Vol. 76, No. 12
0019-9567/08/$08.00+0     doi:10.1128/IAI.00587-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Relapsing Fever Borreliosis in Interleukin-10-Deficient Mice{triangledown}

Diana Londoño,1 Adriana Marques,2 Ronald L. Hornung,3 and Diego Cadavid1*

Department of Neurology and Neuroscience and Center for Emerging Pathogens at UMDNJ-New Jersey Medical School, Newark, New Jersey 07103,1 Clinical Studies Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,2 Clinical Services Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 217023

Received 13 May 2008/ Returned for modification 19 June 2008/ Accepted 8 September 2008

Relapsing fever (RF) is a spirochetal infection characterized by periods of sickness with fever at time of high bacteremia that alternate with afebrile periods of relative well being during low bacteremia. Patients with epidemic RF who are doing relatively well have extraordinarily high levels of interleukin-10 (IL-10) in the circulation. We investigated the possibility that IL-10 plays an important protective role in this infection using wild-type and IL-10-deficient mice inoculated with virulent serotype 2 of the RF spirochete Borrelia turicatae. During peak bacteremia there was increased systemic production of IL-10 that quickly resolved in the postpeak period; in contrast, IL-6 and CXCL13 production increased during the peak but remained elevated during postpeak bacteremia. IL-10 deficiency resulted in lower bacteremia, increased specific antibody production, higher production of CXCL13 and IL-6, and thrombotic and hemorrhagic complications affecting multiple organs with secondary tissue injury. Our results revealed that production of IL-10 is highly regulated during RF and plays an important protective role in the prevention of hemorrhagic and thrombotic complications at the cost of reduced pathogen control.

* Corresponding author. Mailing address: Center for Immunity and Inflammatory Diseases, Massachusetts General Hospital, 149 13th Street, Room 8301, Charlestown, MA 02129. Phone: (617) 679-3680. Fax: (617) 679-3518. E-mail: dcadavid{at}partners.org

{triangledown} Published ahead of print on 15 September 2008.

Editor: J. B. Bliska

Infection and Immunity, December 2008, p. 5508-5513, Vol. 76, No. 12
0019-9567/08/$08.00+0     doi:10.1128/IAI.00587-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Festa, E. D, Hankiewicz, K., Kim, S., Skurnick, J., Wolansky, L. J, Cook, S. D, Cadavid, D. (2009). Serum levels of CXCL13 are elevated in active multiple sclerosis. Mult Scler 15: 1271-1279 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»