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Infection and Immunity, June 2004, p. 3391-3397, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3391-3397.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection

Amélia Ribeiro de Jesus,1 Andréa Magalhães,1 Delfin Gonzalez Miranda,2 Roberval Gonzalez Miranda,2 Maria Ilma Araújo,1 Adriana Almeida de Jesus,1 Angela Silva,3 Luciana B. Santana,3 Edward Pearce,4 and Edgar M. Carvalho1*

Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia,1 Clínica Gonzalez Miranda LTDA, Itaigara, Salvador, Bahia,2 Departamento de Doenças Infecciosas, Universidade Federal de Sergipe, Sergipe, Brazil,3 Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania4

Received 19 December 2003/ Returned for modification 25 January 2004/ Accepted 19 February 2004

The objective of this study was to evaluate the role of cytokines in hepatic fibrosis in the prehepatosplenic and early hepatosplenic stages of schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography of 94 patients. Immunological evaluation was performed by the measurement of secreted cytokines (interleukin-5 [IL-5], IL-10, IL-13, gamma interferon, tumor necrosis factor alpha, and transforming growth factor ß) in peripheral blood mononuclear cells (PBMC) stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10, and IL-13 were found in supernatants of soluble egg antigen-stimulated PBMC from subjects with degree III hepatic fibrosis compared to patients with degree I or II fibrosis. Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for 1 year following initial assessment and developed more serious fibrosis during this period. The data suggest a role for type 2 cytokines in hepatic fibrosis in human schistosomiasis mansoni.

* Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas, S. N., Canela, Salvador, Bahia CEP 40110-160, Brazil. Phone and fax: 55 71 245 7110. E-mail: imuno{at}ufba.br.

Editor: W. A. Petri, Jr.

Infection and Immunity, June 2004, p. 3391-3397, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3391-3397.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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