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Infection and Immunity, October 2000, p. 6052-6055, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Immunization with Alpha-Toxin Toxoid Protects the Cornea against Tissue Damage during Experimental Staphylococcus aureus Keratitis

Emma B. H. Hume,1 Joseph J. Dajcs,1 Judy M. Moreau,1 and Richard J. O'Callaghan1,2,*

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center,1 and the Department of Ophthalmology, Louisiana State University Eye Center,2 New Orleans, Louisiana

Received 17 April 2000/Returned for modification 10 July 2000/Accepted 27 July 2000

Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toxoid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.

* Corresponding author. Mailing address: The Department of Microbiology, Immunology, and Parasitology, LSU Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112. Phone: (504) 568-4072. Fax: (504) 568-2918. E-mail: rocall{at}lsumc.edu.

Infection and Immunity, October 2000, p. 6052-6055, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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